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class="ejfontstyle51088"> 科研创新 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../3list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1029"><span class="ejfontstyle51088"> 教学质量工作 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../3list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1030"><span class="ejfontstyle51088"> 学位工作 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../3list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1116"><span class="ejfontstyle51088"> 校园文化 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../3list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1117"><span class="ejfontstyle51088"> 招生信息 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../3list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1118"><span class="ejfontstyle51088"> 就业信息 </span></a></TD></tr></table></div></td></tr></table></div></td><td></td><td align="left" nowrap><DIV class="main_0_" id="layer_0_1006" onmouseover="tshownull('1006','b2_0_', '_0_')" onmouseout="thideLayers('1006','b1_0_', '_0_','true')" style="z-index:99999;display: none;POSITION: absolute"><TABLE align="center" class="tb1_0_" cellSpacing="0" cellPadding="0" border="0"><tr><TD height="0" nowrap align="left" id="a_0_1042" onmouseover="tshow('1042','b4_0_', this, '_0_')" onmouseout="thideLayers('1042','b3_0_', '_0_')" class="b3_0_"> <a class="menu0_0_" href="../xsgz/jgsz.htm"><span 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class="ejfontstyle51088"> 心理咨询 </span></a></TD></tr></table></div></td></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1101"><span class="ejfontstyle51088"> 学生党建 </span></a></TD></tr><tr><TD height="0" align="left" nowrap onmouseover="TOVT(this,'b4_0_', '_0_');" onmouseout="TOUT(this,'b3_0_', '_0_');" class="b3_0_"> <A class="menu0_0_" href="../list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1102"><span class="ejfontstyle51088"> 创新创业 </span></a></TD></tr></table></div></td><td></td><td align="left" nowrap><DIV class="main_0_" id="layer_0_1008" onmouseover="tshownull('1008','b2_0_', '_0_')" onmouseout="thideLayers('1008','b1_0_', '_0_','true')" style="z-index:99999;display: none;POSITION: absolute"><TABLE align="center" class="tb1_0_" cellSpacing="0" cellPadding="0" border="0"><tr><TD height="0" align="left" nowrap 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_ue_org_tagname="style" _ue_div_style="1"></div> <div> <p><b>一、概?/b></p> <p>医学遗传学教研室拥有一支年龄、学历、知识结构合理的学科队伍,现有专职教?人,其中高级职称3人,中级职称3人,其中博士4人,硕士1人。目前主要承担医学生的医学遗传学、医学遗传学实验、细胞生物学和医学生物学四门课的教学任务,本学科拥有分子遗传学和细胞生物学技术平台,能满足科研工作的基本需要,现有多个稳定的研究方向,近年来主编或参编国家级规划教材《医学遗传学》、《医学细胞生物学》、《医学生物学》等10部教材,承担国家自然科学基金、省卫生厅资助项目等多项国家级、省部级科研项目,在国内外高水平期刊发表论文数十篇,获得省教育厅科技成果一等奖和省卫生厅科技成果三等奖。在教学科研的同时,教研室对外开展染色体检查、遗传病鉴定、遗传咨询等项目已有30多年,发现的三个异常核型经中国医学遗传学国家重点实验室鉴定为世界首次报道的人类染色体异常核型?/p> <p> </p> <p><b>?/b><b>?/b><b>教学工作</b></p> <p><b>1.</b><b>开设课?/b>:医学遗传学教研室承担了本科生、研究生、专升本等各层次教学任务。为医学学科各专业本科学生开设了医学遗传学、医学遗传学实验、细胞生物学和医学生物学等课程,为研究生开设了医学遗传学、医学分子遗传学、细胞生物学的课程。其中,细胞生物学已开展双语教学。医学遗传学和细胞生物学即将为留学生开设全英课程?/p> <p><b> </b></p> <p><b>2.</b><b>教学方法和学科建?/b>:本学科在教学改革与实践中大胆探索,勇于实践,注重运用现代化的教学手段和教学方法,深受学生的广泛欢迎,教学效果优良,多人次在校教学质量奖评比中获奖。承担多项校教改项目及大学生研究训练计划项目等,发表教学论文多篇。学科注重教材建设,多位教师先后参编了普通高等教育“十一”五国家级规划教材《医学生物学》、全国高等医药院校规划教材《医学遗传学》和《医学细胞生物学》等人民卫生出版社、科学出版社等出版发行的论著教材10部?/p> <p><b> </b></p> <p><b>3.</b><b>师资队伍?/b>医学遗传学教研室现有在编教师6人,其中副教?人,讲师3人;4位具有博士学位(其中博士?人),中青年教师?5岁以下)?3%。是一支高学历、年轻化、学术结构合理的团队?b></b></p> <p> </p> <p><b>三、学术研?/b></p> <p><b>1.</b><b>研究方向</b>:本教研室学术气氛浓厚,主要研究方向?/p> <p><a name="_GoBack"></a>(1)人类常见遗传病的检测与咨询。比如唐氏综合症,Turner综合症,原发闭经,少精、无精子症等?/p> <p>(2)肿瘤相关的转录因子在肿瘤发生发展中的作用?/p> <p>(3)维他命K代谢循环相关基因的作用机理,以及这些基因与临床出血或凝血异常的关系?/p> <p>(4)肿瘤相关信号传导通路在肿瘤发生发展过程的的作用及药物靶点的开发?/p> <p><b> </b></p> <p><b>2.</b><b>部分参研项目?/b></p> <p>(1)HIF1 调控SCD1 的机制及其在肝癌中的作用研究?1301076),国家自然科学基金,沈国民主持,沈滟,赵晓参与?/p> <p>(2)解整合素-金属蛋白酶ADAM8在肝细胞癌发生发展中的作用机制研究(81201558),国家自然科学基金,沈国民参与?/p> <p>(3)心肌营养素对阿尔兹海默病转基因模型小鼠脑组织能量代谢的作用及机制研究(U1304806),国家自然科学基金,沈国民参与?/p> <p>(4)二氢黄酮柚皮苷对阿尔茨海默病突触线粒体功能障碍的作用及机制研究(81601225),国家自然科学基金,沈国民,曹青参与?/p> <p>?)胰腺癌细胞中c-Src激酶调控Notch-1活化的分子机制(30873033),国家自然科学基金,刘浩参?/p> <p>?)Notch家族四种蛋白质在胰腺癌细胞基因组的靶基因谱和调控机制的比较研究(81372156),国家自然科学基金,刘浩参?/p> <p><b>3.</b><b>部分代表性论文:</b></p> <p>Xu, X., et al., Analysis of pupylation of Streptomyces hygroscopicus 5008 in vitro.Biochemical& Biophysical Research Communications, 2016. 474(1): p. 126-130.</p> <p>Xu, X.#, Y. Niu, K. Liang, J. Wang, X. Li and Y. Yang*. Heat shock transcription factor δ 32 is targeted for degradation via an ubiquitin-like protein ThiS in Escherichia coli. Biochemical and biophysical research communications 2015, 459 (2): 240-245.</p> <p>Cao Q, Zhang X, Lu L, Yang L, Gao J, Gao Y, Ma H, Cao Y*. (2012) Klf4 is required for germ-layer differentiation and body axis patterning during Xenopus embryogenesis. Development 139:3950-3961. </p> <p>Gao Y, Cao Q, Lu L, Zhang X, Zhang Z, Dong X, Jia W, Cao Y*. (2015) Kruppel-like factor family genes are expressed during Xenopus embryogenesis and involved in germ layer formation and body axis patterning.Development Dynamics. 244(10):1328-46. </p> <p>Lu L, Gao Y, Zhang Z, Cao Q, Zhang X, Zou J, Cao Y*.(2015)  Kdm2a/b Lysine Demethylases Regulate Canonical Wnt Signaling by Modulating the Stability of Nuclear β-Catenin.Development Cell. 33(6):660-74. </p> <p align="left">GuominShen, NingNing, Xingsheng Zhao, Xi Liu, Guangyu Wang, Tianzhen Wang, Ran Zhao, Dongmei Wang, Pingyuan Gong, Yan Shen, Yongjian Sun, Xiao Zhao, Yinji Jin, Weiwei Yang, Yan He, Lei Zhang, Xiaoming Jin, Xiaobo Li. Adipose differentiation-related protein (ADRP) is not involved in hypoxia inducible factor-1(HIF1) induced lipid accumulation under hypoxia. Molecular Medicine Reports. 2015 Dec;12(6):8055-61</p> <p align="left">GuominShen, XiaoboLi, Yong-fengJia, Gary APiazza, YaguangXi. Hypoxia-regulated microRNAs in human cancer.ActaPharmacol Sin.2013, Mar; 34(3):336-341</p> <p>Guo-Min Shen, Ying-Ze Zhao, Ming-Tai Chen, Feng-Lin Zhang, Xiao-Ling Liu, Yi Wang, Chang-Zheng Liu, Jia Yu, Jun-Wu Zhang. Hypoxia Inducible Facter 1 (HIF1) Promotes LDL and VLDL Uptake Through Inducing VLDLR Under Hypoxia. Biochem J, 2012, Jan; 441(2):675-683 </p> <p>Guo-Min Shen, Feng-Lin Zhang, Xiao-Ling Liu, Jun-Wu Zhang. Hypoxia-inducible factor 1-mediated regulation of PPP1R3C promotes glycogen accumulation in human MCF-7 cells under hypoxia. FEBS Lett. 2010, 584(20):4366-4372</p> <p>YuanLiu,YanSHEN,HeLi,HuiWang,Zhen-RongYang,YanChen,Yan-Ping Tang.Intergeneration CAG expansion in a Wuhan juvenile-onset Huntington disease family.NeuroscienceBulietin,July 30,2007,23(4):198-202 </p> <p>Shi, C., Ma, Y., Liu, H. et al. The non-receptor tyrosine kinase c-Src mediates the PDGF-induced association between Furin and pro-MT1-MMP in HPAC pancreatic cellsMol Cell Biochem (2012) 362: 65. doi:10.1007/s11010-011-1128-3</p> <p>沈滟,等.rsTRAIL诱导白血病细胞系HL60凋亡及其作用机制.山东医药?007?7?/p> <p>赵晓,等?6,X,t(X;5;6)(p11.2;q35;q16)一例。《中华医学遗传学杂志?008??/p> <p>赵晓,等;染色体臂内倒位2例。《中华医学遗传学杂志?008??/p> <p>赵晓,等;染色体倒位伴不良生?例。《中国优生与遗传杂志?008??/p> <p>赵晓,等?31例原发性闭经女性的细胞遗传学分?含世界首报异常核??.遗传,2008年第8?(EI收录?/p> <p>赵晓,等;中国人群罗伯逊易位携带者的核型分布与生育情况分析。《中国妇幼保健杂志》,2011?6?/p> <p>赵晓,等?t(7;15)一家系3例。《中华医学遗传学杂志》,2015?0?/p> <p> </p> <p><b>4.</b><b>部分科研成果?/b></p> <p>(1)46,X,t(X;5;6)(p11.2;q35;q16)?007?月由中国医学遗传学国家重点实验室鉴定为世界首次报道的人类染色体异常核型(赵晓?/p> <p>(2)46,X,t(X;1)(q22;p34)?2007?2月由中国医学遗传学国家重点实验室鉴定为世界首次报道的人类染色体异常核型(赵晓?/p> <p>(3)46,XX,t(4; 9)(q21;p22),t(6;10)(p25;q25),t(11;14)(q23;q32)?007?2月由中国医学遗传学国家重点实验室鉴定为世界首次报道的人类染色体异常核型(赵晓?/p> <p align="left">(4)人类指掌皮肤嵴纹与智力发育的相关性研究?998年获河南省科技进步三等奖,沈滟第三?</p> <p>(5)医学生性知识水平的研究?999年获省卫生厅科技成果三等奖,沈滟第三?/p> <p>(6)足纹与智力发育的相关性研究?001年获省卫生厅科技成果三等奖,沈滟第四?/p> <p>(7)饮食限制对大鼠学习记忆、抗氧化能力及端粒酶活性影响的实验研究?014年获河南省教育厅科技成果一等奖,沈滟第三名</p> <p>(8)2007?月指导学生获?届挑战杯河南省大学生课外学术科技作品竞赛三等奖(赵晓?/p> <p> </p> <p></p> </div></td> </tr> </table><!--#endeditable--></DIV><!-- AspNetPager V6.0.0 for VS2005 End --></DIV></DIV></DIV></DIV></DIV><script src="../dfiles/11375/js/jquery-1.3.1.js" type="text/javascript"></script><script src="../dfiles/11375/js/wwwzzjsnet.js" type="text/javascript"></script><LINK rel="stylesheet" href="../dfiles/11375/main/css/iconfont.css"> <DIV class="footer" style="width: 102%;height: 195px"> <DIV class="inner" style="width: 1200px;height: 140px"> <DIV class="link-box" frag="面板99"> <DIV frag="窗口99"> <DIV id="wp_nav_w99" align="center"> <UL class="links-wrap"> <!--#begineditable name="友情链接" viewid="51061"--><script language="javascript" src="../system/resource/js/dynclicks.js"></script><script language="javascript" src="../system/resource/js/openlink.js"></script><UL> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4891)">科大首页</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4892)">科大新闻</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4893)">科大校报</a></li> <LI><a href="../list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1050" title="" onclick="_addDynClicks("wburl", 1224129940, 4894)">招生就业</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4895)">网络服务</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4896)">软件下载</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4897)">图书?/a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4898)">视频电影</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4899)">表格下载</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4900)">教育在线</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4901)">教学评估</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4902)">校园风光</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4903)">洛浦清风</a></li> <LI><a title="" onclick="_addDynClicks("wburl", 1224129940, 4904)">科大BBS</a></li> </UL><!--#endeditable--></UL></DIV></DIV></DIV></DIV> <DIV class="footer_copyright">地址:洛阳市洛龙去开元大?63号(471003?No.6 Anhui Road,Luoyang 471003,China Tel:86-0379-4830346, Fax:86-0379-4830346 E-mail:yxybgs@mail.haust.edu.cn</DIV></DIV></FORM><MAP name="AutoMap1"><AREA shape="rect" target="" coords="0,0,22,9"><AREA shape="rect" target="" coords="0,0,24,7"></MAP><MAP name="AutoMap2"><AREA shape="rect" target="" coords="0,0,22,6"></MAP><MAP name="AutoMap3"><AREA href="../list.jsp?urltype=tree.TreeTempUrl&wbtreeid=1048" shape="rect" target="" coords="0,0,22,6"><AREA href="../xsgz/shsj/sjtp.htm" shape="rect" target="" coords="0,0,23,9"></MAP><MAP name="AutoMap4"><AREA shape="rect" target="" coords="970,17,1031,36"><AREA href="javascript:window.external.AddFavorite(document.location.href,document.title)" shape="rect" target="" coords="1052,18,1105,37" onfocus="blur(this);"></MAP> <a href="http://www.qifaqiche.com/">è</a> <script> (function(){ var bp = document.createElement('script'); var curProtocol = window.location.protocol.split(':')[0]; if (curProtocol === 'https') { bp.src = 'https://zz.bdstatic.com/linksubmit/push.js'; } else { bp.src = 'http://push.zhanzhang.baidu.com/push.js'; } var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(bp, s); })(); </script> </body></HTML>